We are currently performing experiments to determine the pathophysiology of delirium using translational models. By studying the responses of rodents to sedation and inflammation, we can determine which factors are necessary and sufficient to cause delirium-like behavior. Our translational work is rigorously validated using state-of-the-art clinical research scales that were developed to screen for delirium in intubated ICU patients who can not speak.
In order to characterize delirium-related behavior, we leverage cutting-edge, open-source technologies to develop novel and cost-efficient behavioral devices to monitor rodent behavior continuously. By identifying and confirming the factors that can cause delirium, we will be able to determine the brain networks involved in the development and possible treatment of delirium.